Clinical trials - World Health Organization (WHO)
Oct 7, 2025 · Clinical trials are a type of research that studies new tests and treatments and evaluates their effects on human health outcomes.
Clinical Cases - The New England Journal of Medicine
A 70-year-old man presented with several hours of shortness of breath and a slow heart rate that had been detected by the ballistocardiographic monitor in his commercial mattress.
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in …
Jun 21, 2025 · Orforglipron is a small-molecule, nonpeptide glucagon-like peptide-1 (GLP-1) receptor agonist in clinical development for type 2 diabetes and weight management. …
Clinical trials in children - World Health Organization (WHO)
Why perform clinical trials in children? Children are a unique population with distinct developmental and physiological differences from adults. Clinical trials in children are essential …
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes
Jun 20, 2025 · Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase …
Once-Weekly Semaglutide in Adults with Overweight or Obesity
Feb 10, 2021 · The safety of semaglutide was consistent with that reported in the phase 2 study with once-daily dosing in participants with obesity 14 and in the trials of once-weekly …
Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated ...
Apr 30, 2025 · Semaglutide, a glucagon-like peptide-1 receptor agonist, is a candidate for the treatment of metabolic dysfunction–associated steatohepatitis (MASH). In this ongoing phase …
Semaglutide and Cardiovascular Outcomes in Obesity without …
Nov 11, 2023 · Semaglutide, a glucagon-like peptide-1 receptor agonist, has been shown to reduce the risk of adverse cardiovascular events in patients with diabetes. Whether …
International Clinical Trials Registry Platform (ICTRP)
What is a clinical trial? For the purposes of registration, a clinical trial is any research study that prospectively assigns human participants or groups of humans to one or more health-related …
Public disclosure of clinical trial results
Public registration of clinical trials, and the timely and full reporting of their results, are internationally accepted measures to promote transparency, identify existing trials, deter …